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Cancer Immunotherapy
Interferons
Disovered in 1957, interferons underwent purification, cloning, in vitro and in vivo characterisation which culminated in therapeutic applications
The basics
Induction of IFN syntehsis
Pathogen associated molecular patterns recognized by TLRs and cytoplasmic proteins leads to transcription of IFNs
Interferons signal through transmembrane receptors with their associated Janus kinases and STAT molecules
Interferon signalling
IFNs proved effective therapies in a number of cancers, but have now been superceeded by more targeted therapies
Applications in cancer
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